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Mar 30, 2007 · Overall, the weight of evidence from these tests indicates that tramadol does not pose a genotoxic risk to humans. No effects on fertility were observed for tramadol at oral dose levels up to 50 mg/kg 300 mg/m2 in male rats and 75 mg/kg 450 mg/m2 in female rats. Tramadol for Dogs Side Effects, Dosage. the tramadol dosage for dogs can be put into effect by using the dog’s weight as. 90lb Akita 1- 50mg Tramadol pill.